It also has oestrogen-mimicking properties, so check if you are pregnant, breastfeeding, or have a history of certain cancers. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering. Milk thistle and drug interactions are common problems, but can easily be prevented if you take a look at the 3 main medications that you should NOT mix milk thistle with! Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. The phase IV clinical study is created by eHealthMe based on reports of 232 people who take Milk thistle and Metformin from the FDA, and is updated regularly. Herb-drug interactions can be dangerous and, in rare cases, even life-threatening. This study is also expected to take approximately 8 weeks but will involve 18 clinic visits. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs. Top answers from doctors based on your search: Disclaimer. Compounds found in milk thistle – sylibin, sylimarin – act as antioxidants and also stimulate the repair of the liver. Milk thistle + Benzodiazepines. A few include: Cholesterol-lowering medications; Allergy medications; Blood-thinning medications; Some forms of cancer treatment; Anti-anxiety medications; Milk thistle may also be a problem with hormonal birth control, hormone replacement therapy, seizure medications, … Top answers from doctors based on your search: Disclaimer. These medications may interact and cause very harmful effects. Early research suggests that milk thistle may decrease the activity of certain liver enzymes. Find out more on If possible, wait four hours after you take your meds until you take the milk thistle. Answered by Dr. Anne Larson: No Interaction: These medicines do not interact with Milk Thistle. Milk thistle can interact with certain drugs, so check with your GP or a medical herbalist before taking. Not much is known about milk thistle’s food and drug interactions . Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Milk thistle may interact with other drugs. Milk thistle can also be taken with cholesterol-lowering medications, like statins. High blood pressure occurs when the artery wall pressure rises above 120 systolic and 90 diastolic, which is measured in millimeters of mercury. Evidence, mechanism, importance and management Some … Drug Interactions. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Milk thistle does not appear to affect the pharmacokinetics of midazolam. The commonly used herbal supplements selected include Echinacea, Ginkgo biloba, garlic, St. John's wort, goldenseal, and milk thistle. Published February 24 2014. Drugs broken down by the liver. Drug interactions are reported among people who take Losartan potassium and Milk thistle. A 44-year-old member asked: Is there a drug interactions between milk thistle and pomegranate? But milk thistle does not seem to affect how quickly the body breaks down indinavir (Reyataz). Please consult a doctor or healthcare professional before trying any remedies. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Conclusions: HP (especially ginseng, rhadiola rosea, ginkgo biloba, milk thistle) are associated with a significant risk of pharmacokinetic and pharmacodynamic interactions with psychotropic drugs. Milk thistle might increase how quickly the liver breaks down some medications. Below is a short list of some other medications that are processed through the CYP3A4 enzyme. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). It seems that the Milk Thistle does have some positive effects when used with Methadone. See what others have said about Milk Thistle, including the effectiveness, ease of use and side effects. Milk thistle can interact with some medications. Also question is, what medications does milk thistle interfere with? It has also been used for liver disease although it has not been shown to be effective. A Verified Doctor answered. Milk Thistle received an overall rating of 0 out of 10 stars from 0 reviews. 30 July 2001. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. Antiplatelet and anticoagulant drugs (blood thinners). It may lead to hypoglycemia when combined with diabetes medications such as glimepiride (Amaryl). In both studies all subjects will receive the same milk thistle supplement and no placebo will be administered. does milk thistle interact with blood pressure medicine. I’ll always be a bit of stubble growth is noticeable. Anti-anxiety drugs. Milk thistle is often sold as an herbal supplement. Drug interactions are reported among people who take Milk thistle and Metformin. Levels of these medications may increase if taken by people who are also using milk thistle. Because of the resulting complications and side effects, any decision to include a herbal supplement should be preceded by a detailed safety analysis with benefit and risk assessment. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. A warning about milk thistle (silymarin) and drug interactions. Serious Interactions. The phase IV clinical study is created by eHealthMe based on reports of 45 people who take Losartan potassium and Milk thistle from the FDA, and is updated regularly. It seems my dose has been holding him better, meaning a full 24 hours. This is an assessment study of the potential for this botanical extract to interact with other prescription or over-the-counter medications. Milk thistle may raise the levels of a hepatotoxic metabolite of pyrazinamide. Common interactions include insomnia among females and fatigue among males. Allergy Medications . Drug Interactions . Early research suggests that milk thistle may decrease the activity of certain liver enzymes. Milk thistle can increase levels of some drugs and can also lower those levels. To account for the possibility of interference with cytochrome P-450, physicians often advise periodic blood tests to determine drug levels instead of skipping silymarin. Herb / drug interactions: The breakdown of milk thistle by certain liver enzymes may interfere with the action of drugs that are metabolized by those same enzymes. Answered by a verified doctor: No: No there is not. USES: Milk thistle has been used for diabetes in combination with standard treatment. However, little conclusive information is available about milk thistle interactions. Many meds for people with AIDS, for example, are processed by this liver enzyme. "Is there a drug interactions between milk thistle and pomegranate?" For information on the interactions of individual flavonoids present in milk thistle, see under flavonoids. Does Milk Thistle Interfere With Blood Pressure Medication Hep What Does C. 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